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Inflammation + Joint Pain

Joint Health
  • Supports symptoms of mild to moderate osteoarthritis*
  • Supports joint function*
  • Supports joint stiffness*
  • Supports joint comfort*
Levagen® demonstrated a dose-dependent improvement (300mg & 600mg) in WOMAC scores* (discomfort, stiffness and function) compared to the placebo in the management of mild to moderate osteoarthritis 

Levagen® offers morning and evening joint ache reduction when compared to placebo over a 14 day period, suggesting that PEA may be a beneficial and effective treatment for joint pain.* 

Sleep
Levagen® was shown to reduce anxiety* and improve QOL*  providing PEA's relevance and application in sleep.
PEA is part of the extended endocannabinoid family, thus may promote restful sleep through indirect activation of the calm-inducing CB1 receptors. It can also increase restful REM sleep by activating TRPV1 channels*

Sports Performance & Recovery
Recovery · Significantly reduces levels of myoglobin* (a marker for muscle damage) and stimulates the Akt/PkB pathway* (downstream region of the mTOR pathway involved in muscle protein synthesis).
Performance · Significantly reduces lactate levels, allowing to exercise at higher intensities and/or for a longer duration*.

Immune Health
PEA has been shown to optimize the immune system* and provide symptomatic relief of flu symptoms* . This is due to unique actions on numerous pathways, such as activation of PPAR-a and inhibiting mast cell degranulation.
Discomfort and Inflammation
Levagen®+ was proven to reduce diabetic peripheral neuropathic pain* and inflammation* over an 8 week period. 
PEA offers a variety of benefits and has been studied as an alternative to traditional NSAIDS for pain*. Levagen®+ resolved significant headaches*and headache symptoms* faster than a traditional NSAID, without accentuating side effects.
Best pain relief for Hip, Elbow, Knee, Shoulder, Ankle, Finger, TMJ joint pain & Inflammation.

Osteosine

Osteosine enhances the “bone formation” process while decreasing the “bone resorption” process. This means more new bone is being built while less old bone is being dissolved, leading to an overall increase in bone density. Osteosine also works to increase bone structural strength by increasing the width and weight of the trabecula, the “beams” that provide the structural support for the bone, which is critical to bone strength.

OsteoSine is a specialized food and dietary ingredient composed of highly fractionated Cnidium monnieri and Cuscuta chinensis extracts, produced by a proprietary pharmaceutical extraction technology. OsteoSine has been demonstrated in six in vitro and two in vivo studies to promote bone density and structural strength when proper diet and regular exercise are maintained. Specifically, OsteoSine has shown in these studies to

  • Increases bone growth as demonstrated by increased DNA, type I collagen, osteocalcin (OCN), osteopontin (OPN), bone morphogenetic protein 2 (BMP2) in the studied bone cells 
  • Decreases bone degradation as demonstrated by osteoprotegerin expression upregulation
  • Increase bone mineral density by 8 ~ 10% 
  • Increase bone ash weight, calcium, and phosphate content by 3 ~ 5% 
  • Increase trabecula surface area and width 
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. This material is educational in nature and is not intended to serve as regulatory and/or legal advice.

Levagen+® Inflammation + Joint Support - Avani Wellness
Levagen+® Inflammation + Joint Support - Avani Wellness
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Osteosine® Bone Growth + Support - Avani Wellness
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C3 Curcumin Complex® Award-Winning Ingredient Profile - Avani Wellness
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